Ther are several treatmen of PAH (Pulmonary Arterial Hypertension) such as phospodiesterase (PDE) inhibitor eg : sildenafil ; endothelin (ET-1) receptor antagonist, eg : bosentan ; prostacyclin analogue (beraprost Sodium).
at present there is prostacyclin analgue for the treatmen of pulmunari artieal hypertension, wicch provide all charecteristec acton as antiplatelet action, vasodilating action and endothelial protective acton, anti inflammatton, and vascular smoot muscle cell growth inhibitor. with beraprost sodium wich can be administered orally, so it enables the teratmen of administration has been shown (4 year survival rate of 75 %). because of its caracteristic, beraprost sodium considered to be the most soitable first choice drug for PAH.
articel from Annual Scientific Meeting of the indonesia heart associaton
The Current management of pulmunary hypertension by harmani kalim
national cardiovaskuler center harapan Kita jakarta
